Anti-LC3B antibody [EPR18709] - Autophagosome Marker (Ab192890)

MAP1ALC3, MAP1LC3B, Microtubule-associated protein 1 light chain 3 beta, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, MAP1 light chain 3-like protein 2, Microtubule-associated proteins 1A/1B light chain 3B, MAP1A/MAP1B LC3 B, MAP1A/MAP1B light chain 3 B

反应种属:Human, Mouse, Rat
抗原名称:MAP1LC3B
应用:WB, IHC, IF/ICC

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

FURTHER INFORMATION ON SPECIFICITY (Chinese Version) available under the product protocols section. This file includes key technical notes of experience when using this product.

背景信息

Anti-LC3B antibody [EPR18709] - Autophagosome Marker (ab192890) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in ICC/IF, IHC-P and WB. Anti-LC3B antibody [EPR18709] - Autophagosome Marker (ab192890) was first used in a scientific publication in 2017 and has been cited over 468 times in peer reviewed journals. It's performance in Western Blot in human, mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-LC3B antibody [EPR18709] - Autophagosome Marker (ab192890) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-LC3B antibody [EPR18709] - Autophagosome Marker (ab192890) has been confirmed by Western Blot testing in LC3B knockout HepG2 cells ( ab277828 ). Anti-LC3B antibody [EPR18709] - Autophagosome Marker (ab192890) has 17 independent reviews from customers. Anti-LC3B antibody [EPR18709] - Autophagosome Marker (ab192890) specifically detects LC3B (UniProt ID: Q9GZQ8; Molecular weight: 15kDa) and is sold in a convenient trial size to enable initial testing (20 µL) and larger sizes for subsequent scaling up experiments (100 µL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR18709 - ab221794. Antibody clone EPR18709 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, Alexa Fluor ® 647, Alexa Fluor ® 555 ( ab225382, ab225383, ab307768 ). LC3B is a protein involved in autophagy, a process that helps maintain cellular homeostasis by degrading damaged components. In oncology, LC3B is used as a marker to assess autophagy levels in cancer cells, which can influence tumor progression and response to therapy. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (952)

A foam cell-targeted lipophagy restoration strategy stabilizes vulnerable atherosclerotic plaques.

以泡沫细胞为靶点的脂质自噬修复策略可稳定易损的动脉粥样硬化斑块。

Li Heng, Qin Yusheng, Zhang Jianhong, Guo Xinlin, Hu Xiaolin, Sun Danlei, Zhao Yue, Bernardini Sergio, Xu Daqian, Jiang Peng, Zhang Hong, Luo Yang

ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease.

ESRRA-ATG5介导的线粒体自噬增强精氨酸代谢,从而缓解糖尿病肾病。

Hu Hongtu, Yang Qian, Hu Jijia, Fan Yanqing, Zhang Zongwei, Yang Keju, Li Weiwei, Peng Zhuan, Chen Zhaowei, Ding Guohua, Liang Wei

XIAP-ULK1-mediated mitophagy modulates carnitine metabolism to mitigate diabetic kidney disease.

XIAP-ULK1介导的线粒体自噬调节肉碱代谢,从而减轻糖尿病肾病。

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1.

TP53BP2 通过 G9a 和 DNMT1 协同调节 E2F1 促进胎盘自噬和先兆子痫。

Biallelic GLTP mutations cause nonsyndromic epidermal differentiation disorder via disrupted epidermal glucosylceramide transport.

双等位基因 GLTP 突变通过破坏表皮葡糖基神经酰胺的转运,导致非综合征性表皮分化障碍。

Zhang Zeqiao, Huang Shimiao, Jackson Adam, Jones Elizabeth A, Banka Siddharth, Yang Chao, Zhao Sisi, Lv Kunlun, Peng Sha, Lin Zhimiao, Wang Huijun

Distinct neuronal alterations distinguish two subtypes of sporadic Creutzfeldt-Jakob disease with shared dysfunctional pathways.

散发性克雅氏病的两个亚型具有不同的神经元改变,但它们都存在共同的功能障碍通路。

Williams Katie, Groveman Bradley R, Foliaki Simote T, Race Brent, Hay Arielle, Walters Ryan O, Thomas Tina, Zanusso Gianluigi, Carroll James A, Haigh Cathryn L

Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.

缺血再灌注后,微血管内皮代谢功能障碍通过生物能量衰竭驱动脑水肿。

Zhou Yi-Fan, Yang Si-Bo, Zhang Feng, Sun Xiao-Di, Chang Bo-Hao, Li Ya-Nan, Wu Jie-Hong, Jin Hui-Juan, Huang Ming, Chen Sheng-Cai, Yang Hang, Zhu Dong-Ya, Menon Bijoy K, Hu Bo

Targeted inhibition of RGS19 alleviates renal fibrosis by restoring autophagy and modulating immune cell infiltration.

靶向抑制 RGS19 可通过恢复自噬和调节免疫细胞浸润来缓解肾纤维化。

Niu Xinhao, Zhao Yufeng, Li Long, Xu Xiaoqing, Xu Cuidi, Wu Jiaheng, Yu Xiaohan, Chen Yanbo, Rong Ruiming, Xu Bin

Lactate-driven ATP6V1B2 lactylation triggers asthmatic inflammation by linking lysosomal dysfunction to mitochondrial ROS-dependent pyroptosis.

乳酸驱动的 ATP6V1B2 乳酸化通过将溶酶体功能障碍与线粒体 ROS 依赖性细胞焦亡联系起来,从而引发哮喘炎症。

Migrasome-mediated clearance of excess PLK4 defines a targetable vulnerability.

迁移体介导的过量 PLK4 清除定义了一个可靶向的脆弱性。

Ma Jihong, Guo Yuhan, Jiang Yuening, Wang Qilong, Bi Meiyu, Wang Tianzhen, Xiao Yinan, Zhang Na, Wang Pan, Wu Yu, Xie Bingteng, Wang Gang, Li Mo
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