Anti-GRP78 BiP antibody (Ab21685)
GRP78, HSPA5, Endoplasmic reticulum chaperone BiP, 78 kDa glucose-regulated protein, Binding-immunoglobulin protein, Heat shock protein 70 family protein 5, Heat shock protein family A member 5, Immunoglobulin heavy chain-binding protein, GRP-78, BiP, HSP70 family protein 5
详细信息
特异性
Replenishment batches of our polyclonal antibody, ab21685 are tested in WB. Previous batches were additionally validated in ICC/IF and IHC-P. These applications are still expected to work and are covered by our Abpromise guarantee. You may also be interested in our alternative recombinant antibody, ab108613.
背景信息
Anti-GRP78 BiP antibody (ab21685) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human, mouse, recombinant fragment samples. Anti-GRP78 BiP antibody (ab21685) has been cited over 646 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-GRP78 BiP antibody (ab21685) has high sensitivity and specificity. Anti-GRP78 BiP antibody (ab21685) has 71 independent reviews from customers. Anti-GRP78 BiP antibody (HSPA5 antibody) (ab21685) specifically detects GRP78 BiP (UniProt ID: P20029; Molecular weight: 70kDa) and is sold in 100 µg selling sizes. GRP78 (Glucose-Regulated Protein 78), also known as BiP(Binding Immunoglobulin Protein) or heat shock 70 kDa protein 5 (HSPA5), is a crucial endoplasmic reticulum (ER) chaperone protein that is often overexpressed in cancer cells. It helps cancer cells survive under stressful conditions by regulating the ER stress response and preventing apoptosis. Additionally, GRP78 helps maintain the tumor microenviroment and support cancer stem cells properties, promoting tumor growth and metastasis. Stimulation may be required to allow detection of the target protein due to low levels of endogenous expression in some samples. Please see images below for recommended treatment conditions and positive controls.
文献引用 (708)
Biocompatible ligand balancing in transition metal coordination enables benign in-cell protein arylation.
过渡金属配位中生物相容性配体的平衡能够实现良性的细胞内蛋白质芳基化。
SEL1L-HRD1 ER-associated degradation facilitates prohormone convertase 2 maturation and glucagon production in islet α cells.
SEL1L-HRD1 ER 相关降解促进胰岛α细胞中前激素转化酶 2 的成熟和胰高血糖素的产生。
Non-Targeting shRNA-Encoded Plasmid DNA Enhances Protective Immunity Through RIDD-RIG-I Signaling Pathway in the Zika Virus Animal Model.
非靶向 shRNA 编码的质粒 DNA 通过 RIDD-RIG-I 信号通路增强寨卡病毒动物模型的保护性免疫。
Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR-Mediated Control of Immunoglobulin Homeostasis in Hybridomas.
定量蛋白质组学和 CRISPR/Cas9 编辑揭示了 UPR 介导的杂交瘤免疫球蛋白稳态控制。
Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology.
工程化GM1连接线粒体和突触通路，以改善ALS病理。
Early Transcriptomic and Pathologic Changes of Col8a2 Mutant Fuchs Endothelial Corneal Dystrophy.
Col8a2突变型Fuchs内皮角膜营养不良的早期转录组学和病理学变化。
RhoA accelerates atherosclerosis progression by interacting with Hspa5.
RhoA 通过与 Hspa5 相互作用加速动脉粥样硬化的进展。
Mechanistic role of GNE-987 targeting BRD4-HCP5 axis in pediatric T-cell acute lymphoblastic leukemia.
GNE-987靶向BRD4-HCP5轴在儿童T细胞急性淋巴细胞白血病中的机制作用。
Obesity as a Determinant of Periodontal Therapy Outcomes: Insights on Oxidative and Endoplasmic Reticulum Stress Pathways.
肥胖作为牙周治疗结果的决定因素：氧化和内质网应激途径的见解。
Indole-3-carbinol ameliorates ER stress-mediated hyperleptinemia in western diet-fed apoE(-/-) mice.
吲哚-3-甲醇可改善以西方饮食喂养的 apoE(-/-) 小鼠的内质网应激介导的高瘦素血症。
- 1
- 2
- 3
- 4
- 5
- 6
- 71