Anti-Calnexin antibody - ER Marker (Ab22595)
Calnexin, IP90, Major histocompatibility complex class I antigen-binding protein p88, p90, CANX
详细信息
特异性
Recognizes ER membrane, mitochondria and cis-Golgi
背景信息
Anti-Calnexin antibody - ER Marker (ab22595) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IP, WB in human samples. Anti-Calnexin antibody - ER Marker (ab22595) has been cited over 482 times in peer reviewed journals, has been used for calnexin staining and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Calnexin antibody - ER Marker (ab22595) has high sensitivity and specificity. The specificity of Anti-Calnexin antibody - ER Marker (ab22595) has been confirmed by testing in knockout samples. Anti-Calnexin antibody - ER Marker (ab22595) has 28 independent reviews from customers. Anti-Calnexin antibody - ER Marker (ab22595) specifically detects Calnexin (UniProt ID: P27824; Molecular weight: 65kDa) and is sold in 100 µg selling sizes. Calnexin, an endoplasmic reticulum (ER) chaperone protein, plays a crucial role in oncology by influencing the immune response to tumors and cancer cell behavior. It can impair antitumor immunity by inhibiting T-cell infiltration and enhancing PD-1 expression on T cells, which suppresses their activity. Additionally, aberrant O-glycosylation of calnexin is linked to increased cancer cell migration and adhesion. Explore our range of organelle-specific antibodies and dyes and discover why our reagents are deeply trusted by cell biologists.
文献引用 (764)
A small molecule VDAC ligand inhibits ERAD and induces selective cancer cell death via disruption of calcium homeostasis.
一种小分子 VDAC 配体通过破坏钙稳态抑制 ERAD 并诱导选择性癌细胞死亡。
O-GlcNAcylation of AMFR stabilizes TSPAN4 to regulate migrasome formation for viral release.
AMFR 的 O-GlcNAc 化可稳定 TSPAN4，从而调节迁移体的形成以释放病毒。
Extracellular Vesicles Coordinate Bacterial Cloaking in Lung Epithelial Cells to Alleviate Acute Inflammatory Injury.
细胞外囊泡协调肺上皮细胞中的细菌隐蔽作用，以减轻急性炎症损伤。
Alphaherpesvirus UL48 homologs degrade STING1 by selective autophagy.
α疱疹病毒UL48同源物通过选择性自噬降解STING1。
XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.
XIAP 稳定 DDRGK1 以促进内质网吞噬并防止噪声引起的听力损失。
Activating the Osteoblastic USP26 Pathway Alleviates Multi-Organ Fibrosis by Decreasing Insulin Resistance.
激活成骨细胞 USP26 通路可通过降低胰岛素抵抗来缓解多器官纤维化。
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-mediated regeneration.
TP53/TAU轴调节微管束形成，从而控制肺泡干细胞介导的再生。
Extracellular vesicle-based bumetanide delivery alleviates depression-like behaviors of male mice by restoring chloride homeostasis.
通过细胞外囊泡递送布美他尼可恢复氯离子稳态，从而缓解雄性小鼠的抑郁样行为。
Aptamer-functionalized exosomes combined with doxorubicin suppress GBM progression and enhance chemoradiosensitivity by promoting pyroptosis.
适体功能化的外泌体与阿霉素联合使用，通过促进细胞焦亡抑制胶质母细胞瘤进展并增强化疗和放射敏感性。
Exercise-primed exosomes in an injectable hydrogel promote myocardial repair via angiogenesis and ferroptosis inhibition.
注射式水凝胶中的运动预处理外泌体通过血管生成和抑制铁死亡促进心肌修复。
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