Anti-LAMP1 antibody [1D4B] - Lysosome Marker (Ab25245)
CD107a, Lysosome-associated membrane glycoprotein 1, LAMP-1, Lysosome-associated membrane protein 1, CD107 antigen-like family member A, LAMP1
用户验证的应用
推荐稀释比例
- IHC-P10 µg/mL Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.
- Flow Cyt (Intra)1 µg for 10^6 Cells ab18450 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
详细信息
背景信息
Anti-LAMP1 antibody [1D4B] (ab25245) is a rat monoclonal antibody and is validated for use in Flow Cyt (Intra), IHC-P in mouse samples. Anti-LAMP1 antibody [1D4B] (ab25245) has been cited over 211 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-LAMP1 antibody [1D4B] (ab25245) has high sensitivity and specificity. Anti-LAMP1 antibody [1D4B] (ab25245) has 16 independent reviews from customers. Anti-LAMP1 antibody [1D4B] (ab25245) specifically detects LAMP1 (UniProt ID: P11279; Molecular weight: 42kDa) and is sold in 100 µg selling sizes. Antibody clone 1D4B is also available pre-conjugated to FITC for your convenience ( ab24871 ). LAMP1 (Lysosomal Associated Membrane Protein 1) is a protein integral to the lysosomal membrane, playing a significant role in lysosomal stability and cellular waste management. It is commonly used as a lysosome membrane marker in research. Alterations in LAMP1 expression have been implicated in several diseases, such as cancer, where it may aid in metastasis, and neurodegenerative diseases like Alzheimer's disease, where lysosomal dysfunction is a contributing factor. REACH authorisation Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances. It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
文献引用 (229)
Neurons with granulovacuolar degeneration bodies are resilient to tau-induced protein synthesis impairment.
具有颗粒空泡变性体的神经元对 tau 蛋白诱导的蛋白质合成障碍具有抵抗力。
OSBPL10 alleviates neuronal ferroptosis via lysosomal membrane repair in a PS-dependent manner after spinal cord injury.
脊髓损伤后，OSBPL10 通过 PS 依赖性方式修复溶酶体膜，从而减轻神经元铁死亡。
Aberrant mitochondrial hsp60 expression affects mitochondria homeostasis and results in muscle dystrophy and premature death.
线粒体 hsp60 表达异常会影响线粒体稳态，导致肌肉营养不良和过早死亡。
Engineering chimeric antigen receptor CD4 T cells for Alzheimer's disease.
利用工程技术构建嵌合抗原受体CD4 T细胞用于治疗阿尔茨海默病。
Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice.
SAP-D 缺陷小鼠在穹窿下器官周围积累前淀粉样蛋白和前颗粒蛋白，导致烦渴。
Molecular characterization of endosomal self RNA Rmrp-engaged TLR3 dimerization to prime innate activation.
内体自身RNA Rmrp参与TLR3二聚化启动先天激活的分子特征。
Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins
利用人诱导多能干细胞来源的小胶质细胞将疾病修饰蛋白递送至中枢神经系统各处
Targeting the Dependence on PIK3C3-mTORC1 Signaling in Dormancy-Prone Breast Cancer Cells Blunts Metastasis Initiation.
靶向抑制休眠型乳腺癌细胞对 PIK3C3-mTORC1 信号的依赖性可抑制转移的发生
Defective autophagy in CD4 T cells drives liver fibrosis via type 3 inflammation
CD4 T细胞自噬缺陷通过3型炎症驱动肝纤维化。
Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health
在桑德霍夫病小鼠模型中进行的小胶质细胞替代实验表明，髓系来源的β-己糖胺酶对神经元健康至关重要。
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