Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (Ab209538)

NACP, PARK1, SNCA, Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor

反应种属:Human
抗原名称:SNCA
应用:IHC, IF/ICC, Dot

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

This antibody mainly recognizes alpha synuclein Filament, but also has weak cross-reactivity with alpha synuclein Monomer.

背景信息

Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, ICC/IF, IHC-P in human samples. Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) has been cited over 73 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Alpha-synuclein aggregate antibody (Anti-SNCA antibody) [MJFR-14-6-4-2] - Conformation-Specific (ab209538) has 6 independent reviews from customers. Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) specifically detects Alpha-synuclein aggregate (UniProt ID: P37840; Molecular weight: 14kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone MJFR-14-6-4-2 - ab214033. Antibody clone MJFR-14-6-4-2 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Biotin, Alexa Fluor® 594 ( ab216124, ab216309, ab227047, ab283628 ). Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) was developed by Abcam in partnership with the Michael J. Fox Foundation for Parkinson's Research. ab209538 is not suitable for WB or other denaturing conditions, as it is conformation-specific. This antibody is useful for studying Parkinson's disease and other synucleinopathies including dementia with Lewy bodies and multiple system atrophy. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Collaborations This antibody was developed with support from The Michael J. Fox Foundation.

文献引用 (112)

NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway.

在帕金森病小鼠模型中,NLRP3 通过 SATB1/DNA 损伤/p21 信号通路促进 α-突触核蛋白诱导的多巴胺能神经元衰老。

Chen Lei-Lei, Shen Qing-Qing, Sun Li-Ping, Song Yu-Xiang, Jia Wen-Ting, Qu Le, Xie Jun-Xia

Higher-molecular-weight a-synuclein oligomers are increased in the brain cytosol of patients with dementia with Lewy bodies.

路易体痴呆症患者的脑细胞质中高分子量α-突触核蛋白寡聚体增多。

Gregersen Emil, Antorini Mia R, Reimer Lasse, Zaccagnini Ludovica, Selkoe Dennis, Bartels Tim, Jensen Poul Henning

Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.

帕金森病微生物组中减少的普拉梭菌(Faecalibacterium prausnitzii)可改善α-突触核蛋白过表达小鼠的运动缺陷。

Moiseyenko Anastasiya, Antonello Giacomo, Schonhoff Aubrey M, Boktor Joseph C, Long Kaelyn, Dirks Blake, Oguienko Anastasiya D, Winnett Alexander Viloria, Simpson Patrick, Daeizadeh Dorsa, Ismagilov Rustem F, Krajmalnik-Brown Rosa, Segata Nicola, Waldron Levi D, Mazmanian Sarkis K

Direct current stimulation induced reduction in α-synuclein in primary neurons: targeting Parkinson's disease.

直流电刺激诱导原代神经元中α-突触核蛋白减少:靶向治疗帕金森病。

Bechkos Sophie, Ryan Scott D, Ross Alysia, Sun Hongyu, Hayley Shawn

Structure-Based Selection of a Tetracycline Derivative for Advanced Biosensor Platforms Targeting Aggregated α-Synuclein in Parkinson's Disease.

基于结构的四环素衍生物选择用于靶向帕金森病中聚集的α-突触核蛋白的先进生物传感器平台。

Machin Belén, Soliz Santander Silvana, Pernicone Agustín O, Velez Eva M M, Manzano Verónica E, González-Lizárraga Florencia, Madrid Rossana E, Avila César L, Vera Pingitore Esteban, Varela Oscar, Chehín Rosana

Multiomic Analysis Reveals Molecular Pathways Associated with Intestinal Aggregation of α-Synuclein.

多组学分析揭示与肠道α-突触核蛋白聚集相关的分子通路。

Balsamo Julia M, Yan Ying, Thai Dylan, Cologna Stephanie M, Bess Elizabeth N

Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology

重组组织蛋白酶B和L促进α-突触核蛋白的清除,并恢复人类和鼠类α-突触核蛋白病理模型中的溶酶体功能。

Denise Balta # ,Anish Varghese # ,Susy Prieto Huarcaya # ,Alessandro Di Spiezio ,André R A Marques ,Enes Yağız Akdaş ,Doğa Tabakacilar ,Alice Drobny ,Christian Werner ,Wei Xiang ,Rebecca Mächtel ,Jan Philipp Dobert ,Anna Fejtova ,Franziska Richter ,Melanie Küspert ,Philipp Arnold ,Paul Saftig ,Friederike Zunke

Unraveling α-synuclein and amylin co-aggregation: pathological insights and biomarker development for Parkinson's disease.

揭示α-突触核蛋白和胰淀素共聚集:帕金森病的病理学见解和生物标志物开发

Zhou Yuhang, Lai Minchao, Shu Bowen, Wang Benguo, Wang Dian, Liu Haoran, Li Baowan, Guo Jianhe, Hu Dongjie, Li Mingyuan, Zhu Cheng, Kang Muzhi, Li Zhong Alan, Wang Renzhi, Zhao Yongjuan, Tuan Rocky S, Guo Keying, Li Chenzhong, Jiang Cheng

PINK1 deficiency permits the development of Lewy body dementia with coexisting Aβ pathology.

PINK1 缺乏症可导致路易体痴呆症的发生,并伴有 Aβ 病理。

Gao Tong-Yao, Wang Xu-Zheng, Xie Yu-Han, Wang Tong, Lu Yun-Bi, Huang Lu-Long, Chen Cong, Zhang Ming, Ma Xin, Chen Ya-Ling, Liang Fu-Xiang, Lou Zhi-Ling, Li Jin-Sheng, Yu Yi-Fan, Wu Jian-Bin, Ma Xiao-Ru, Wang Hua-Li, Tang Chun, Zhang Wei-Ping

Pathological role of immunoproteasome PSMB8 in Parkinson's disease: a link between α-synuclein aggregation and immune activation

免疫蛋白酶体PSMB8在帕金森病中的病理作用:α-突触核蛋白聚集与免疫激活之间的联系

Huu Dat Nguyen ,Hoang Bao Tram Tran ,Thanh Trung Nguyen ,In Hee Kwak ,Yun Joong Kim ,Hyeo-Il Ma ,Han-Joon Kim ,Young Eun Kim
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