Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (Ab209538)
NACP, PARK1, SNCA, Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor
详细信息
特异性
This antibody mainly recognizes alpha synuclein Filament, but also has weak cross-reactivity with alpha synuclein Monomer.
背景信息
Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, ICC/IF, IHC-P in human samples. Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) has been cited over 73 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-Alpha-synuclein aggregate antibody (Anti-SNCA antibody) [MJFR-14-6-4-2] - Conformation-Specific (ab209538) has 6 independent reviews from customers. Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) specifically detects Alpha-synuclein aggregate (UniProt ID: P37840; Molecular weight: 14kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone MJFR-14-6-4-2 - ab214033. Antibody clone MJFR-14-6-4-2 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, Biotin, Alexa Fluor® 594 ( ab216124, ab216309, ab227047, ab283628 ). Anti-Alpha-synuclein aggregate antibody [MJFR-14-6-4-2] - Conformation-Specific (ab209538) was developed by Abcam in partnership with the Michael J. Fox Foundation for Parkinson's Research. ab209538 is not suitable for WB or other denaturing conditions, as it is conformation-specific. This antibody is useful for studying Parkinson's disease and other synucleinopathies including dementia with Lewy bodies and multiple system atrophy. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies. Collaborations This antibody was developed with support from The Michael J. Fox Foundation.
文献引用 (112)
NLRP3 facilitates α-synuclein-induced dopaminergic neuronal senescence in a mouse model of Parkinson's disease through SATB1/DNA damage/p21 signaling pathway.
在帕金森病小鼠模型中,NLRP3 通过 SATB1/DNA 损伤/p21 信号通路促进 α-突触核蛋白诱导的多巴胺能神经元衰老。
Higher-molecular-weight a-synuclein oligomers are increased in the brain cytosol of patients with dementia with Lewy bodies.
路易体痴呆症患者的脑细胞质中高分子量α-突触核蛋白寡聚体增多。
Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.
帕金森病微生物组中减少的普拉梭菌(Faecalibacterium prausnitzii)可改善α-突触核蛋白过表达小鼠的运动缺陷。
Direct current stimulation induced reduction in α-synuclein in primary neurons: targeting Parkinson's disease.
直流电刺激诱导原代神经元中α-突触核蛋白减少:靶向治疗帕金森病。
Structure-Based Selection of a Tetracycline Derivative for Advanced Biosensor Platforms Targeting Aggregated α-Synuclein in Parkinson's Disease.
基于结构的四环素衍生物选择用于靶向帕金森病中聚集的α-突触核蛋白的先进生物传感器平台。
Multiomic Analysis Reveals Molecular Pathways Associated with Intestinal Aggregation of α-Synuclein.
多组学分析揭示与肠道α-突触核蛋白聚集相关的分子通路。
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysosomal function in human and murine models with α-synuclein pathology
重组组织蛋白酶B和L促进α-突触核蛋白的清除,并恢复人类和鼠类α-突触核蛋白病理模型中的溶酶体功能。
Unraveling α-synuclein and amylin co-aggregation: pathological insights and biomarker development for Parkinson's disease.
揭示α-突触核蛋白和胰淀素共聚集:帕金森病的病理学见解和生物标志物开发
PINK1 deficiency permits the development of Lewy body dementia with coexisting Aβ pathology.
PINK1 缺乏症可导致路易体痴呆症的发生,并伴有 Aβ 病理。
Pathological role of immunoproteasome PSMB8 in Parkinson's disease: a link between α-synuclein aggregation and immune activation
免疫蛋白酶体PSMB8在帕金森病中的病理作用:α-突触核蛋白聚集与免疫激活之间的联系
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