Anti-GSDMD antibody [EPR19828] (Ab209845)
Gsdmdc1, Gsdmd, Gasdermin-D, Gasdermin domain-containing protein 1
详细信息
特异性
In our hands this product works well in western blot using mouse cell lines but not tissue samples. We recommend ab219800 as an alternative for low expression samples. Expression level of GSDMD in whole normal brain lysate is low or undetectable (PMID: 32671214, PMID: 34975487). Please navigate to the Product Protocol section for specificity details in Chinese.
背景信息
Anti-GSDMD antibody [EPR19828] (ab209845) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in IP and WB. Anti-GSDMD antibody [EPR19828] (ab209845) was first used in a scientific publication in 2018 and has been cited over 275 times in peer reviewed journals. It's performance in Western blot in mouse samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-GSDMD antibody [EPR19828] (ab209845) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-GSDMD antibody [EPR19828] (ab209845) has been confirmed by Western Blot testing in GSDMD knockout RAW 264.7 cells. Anti-GSDMD antibody [EPR19828] (ab209845) specifically detects GSDMD (UniProt ID: Q9D8T2; Molecular weight: 54kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR19828 - ab225867. Gasdermin D (GSDMD) is crucial in inflammasomes for executing pyroptosis and releasing pro-inflammatory cytokines. GSDMD is implicated in autoimmune diseases like IBD. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (517)
NEDD4L-mediated Gasdermin D and E ubiquitination regulates cell death and tissue injury.
NEDD4L 介导的 Gasdermin D 和 E 泛素化调节细胞死亡和组织损伤。
A novel lncRNA, lncMCL1, modulates neural pyroptosis associated with epilepsy via stabilizing DDX3X.
一种新型 lncRNA，lncMCL1，通过稳定 DDX3X 来调节与癫痫相关的神经元焦亡。
Neddylation Targets and Stabilizes NLRP3 to Augment Inflammasome-Mediated Colitis and Mood Disorder.
Neddylation 靶向并稳定 NLRP3 以增强炎症小体介导的结肠炎和情绪障碍。
Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip.
预防性补充生物源硒纳米颗粒通过抑制上皮免疫细胞间的相互作用，减轻了肠道屏障的氧化损伤（肠道芯片）。
Biomineralized OMV-based nanocomposite orchestrates cascade-amplified antitumor immunity via eliciting dual pyroptosis and blocking autophagy.
基于生物矿化 OMV 的纳米复合材料通过诱导双重细胞焦亡和阻断自噬来协调级联放大的抗肿瘤免疫。
Caspase-3/7 deficiency results in enhanced intestinal inflammation and reduced tumorigenesis.
Caspase-3/7 缺乏会导致肠道炎症加剧和肿瘤发生减少。
Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease.
人体免疫系统对膳食酒精的感知会引发炎症，从而导致酒精相关疾病。
Multifunctional nanofibrous membranes enhance diabetic wound healing by inhibiting endothelial pyroptosis and regulating macrophage polarization.
多功能纳米纤维膜通过抑制内皮细胞焦亡和调节巨噬细胞极化来促进糖尿病伤口愈合。
Tripartite motif 13 orchestrates endoplasmic reticulum-associated degradation and endoplasmic reticulum-phagy to modulate dendritic cell-mediated immune responses in sepsis.
三方基序 13 协调内质网相关降解和内质网吞噬，从而调节脓毒症中树突状细胞介导的免疫反应。
Histone demethylase KDM4B epigenetically controls NLRP3 expression to enhance inflammatory responses.
组蛋白去甲基化酶 KDM4B 通过表观遗传学控制 NLRP3 的表达，从而增强炎症反应。
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