Anti-PD-L1 antibody [EPR19759] (Ab213524)

CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1

反应种属:Human
抗原名称:CD274
应用:WB, IHC, FCM, IF/ICC, IP

详细信息

免疫原The exact immunogen used to generate this antibody is proprietary information.
宿主/亚型Rabbit / IgG
抗体类型Monoclonal
产品形式Liquid
纯化方式Affinity purification Protein A
储存缓冲液pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
储存条件运输条件: Conditional Ambient 推荐的短期储存时间: 1-2 weeks 推荐的短期储存条件: +4°C 推荐的长期储存条件: -20°C 储存信息: Avoid freeze / thaw cycle
无载体蛋白No

特异性

FURTHER INFORMATION ON SPECIFICITY (Chinese Version) available under the product protocols section. This file includes key technical notes of experience when using this product.

背景信息

Anti-PD-L1 antibody [EPR19759] (ab213524) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human samples. Anti-PD-L1 antibody [EPR19759] (ab213524) has been cited over 96 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-PD-L1 antibody [EPR19759] (ab213524) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PD-L1 antibody [EPR19759] (ab213524) has been confirmed by testing in knockout samples. Anti-PD-L1 antibody [EPR19759] (ab213524) specifically detects PD-L1 (UniProt ID: Q9NZQ7; Molecular weight: 31kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR19759 - ab221612. Antibody clone EPR19759 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, Alexa Fluor® 594, Alexa Fluor® 568 ( ab214958, ab215251, ab215349, ab216742, ab22314 ). Programmed death-ligand 1 (PD-L1) is a critical protein in immuno-oncology, playing a significant role in tumor immune evasion. It is expressed on the surface of tumor cells and binds to the PD-1 receptor on T cells, inhibiting their activity and allowing tumors to escape immune detection. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.

文献引用 (169)

MCUB Inhibits PRKN-Dependent Mitophagic Degradation of PD-L1 to Promote Immune Evasion in Bladder Cancer.

MCUB抑制PRKN依赖的PD-L1线粒体自噬降解,从而促进膀胱癌的免疫逃逸。

Dual-dimensional profiling of host genomic variations and HPV integration in PD-L1-stratified cervical cancer via Oxford Nanopore Technology.

利用牛津纳米孔技术对PD-L1分层宫颈癌中的宿主基因组变异和HPV整合进行双维分析。

Lu Ruijiao, Zhang Jie, Ma Xiumin, Feng Yangchun

MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway.

MMP11 通过 PD-L1/c-Myc 信号通路促进食管癌细胞的免疫逃逸。

Li Shixing, Lou Xuelei, Chang Zukuan, Liu Jinzhan, Lu Huilin

Gut Associated Metabolites Enhance PD-L1 Blockade Efficacy in Prostate Cancer.

肠道相关代谢物增强 PD-L1 阻断剂在前列腺癌中的疗效。

Liu Ke, Xue Xia, Qin Haiming, Zhu Jiaying, Jin Meng, Dai Die, Tang Youcai, Bukhari Ihtisham, Liu Hangfan, Qiu Chunjing, Ren Feifei, Zheng Pengyuan, Mi Yang, Chen Weihua

Pan-cancer analysis of TRPV1: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.

TRPV1 的泛癌分析:一种用于肿瘤预后和免疫治疗反应预测的新型免疫浸润相关生物标志物。

Wang Feixiang, Deng Boyun, Qin Maohua, Cheng Zijin, Zhang Jian, Xie Guofeng

Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma

双重靶向 PD-L1 和 4-1BB 以克服滤泡性淋巴瘤中树突状细胞介导的来那度胺耐药性

Zhong Zheng #, Jian-Biao Wang #, Rui Sun #, Nan Wang #, Xiang-Qin Weng #, Tian-Yuan Xu, Di Fu, Yan Feng, Peng-Peng Xu, Shu Cheng, Li Wang, Yan Zhao, Bin Qu, Chuan-Xin Huang, Wei-Li Zhao

Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma.

PD-L1琥珀酰化改变影响黑色素瘤的抗肿瘤免疫反应

Liang Long, Kuang Xinwei, He Yi, Zhu Lin, Lau Poyee, Li Xin, Luo Dingan, Gong Lan, Zhou Wenbin, Zhang Fanglin, Liang Xiaowei, Li Zhuofeng, Hu Bin, Liu Dandan, Ding Tao, Li Hui, Zhao Shuang, Su Juan, Hung Mien-Chie, Liu Jing, Liu Hong, Chen Xiang

Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.

靶向分子伴侣介导的自噬可抑制胶质母细胞瘤干细胞的特性并恢复抗肿瘤免疫力。

Li Yonghua, Sheng Min, Li Weijie, Liu Simin, Wang Botao, Liu Bing, Luo Mei, Zhou Xiao, Xia Qiaoxi, Hong Shihong, Zheng Ziyuan, Cheng Shi-Yuan, Jiang Xiaobing, Li Junjun, Huang Tianzhi

Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway

抑制肿瘤内在的NAT10可通过MYC/CDK2/DNMT1通路触发I型干扰素反应,从而增强抗肿瘤免疫力。

Wan-Cheng Liu # ,Yi-Hong Wei # ,Jin-Feng Chen # ,Xiang-Ling Xing ,He-Xiao Jia ,Xin-Yu Yang ,Ying-Jian Huang ,Xiao-Min Liu ,Ke Xiao ,Xiao-Dong Guo ,Can Can ,A-Min Zhang ,Na He ,Hai-Lei Zhang ,Dao-Xin Ma

Early growth response 1 as a key regulator of PD-L1 expression and immune evasion in extranodal NK/T-cell lymphoma

早期生长反应1是结外NK/T细胞淋巴瘤中PD-L1表达和免疫逃逸的关键调节因子

Ji Yun Lee ,Kui-Jin Kim ,Woochan Park ,Jeongmin Seo ,Minsu Kang ,Eun Hee Jung ,Sang-A Kim ,Koung Jin Suh ,Ji-Won Kim ,Se Hyun Kim ,Jeong-Ok Lee ,Jin Won Kim ,Yu Jung Kim, Keun-Wook Lee ,Jee Hyun Kim ,Soo-Mee Bang ,Tae Min Kim ,Jin Ho Paik
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