Anti-PD-L1 antibody [EPR19759] (Ab213524)
CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1, Programmed cell death 1 ligand 1, PD-L1, PDCD1 ligand 1, Programmed death ligand 1, hPD-L1, B7 homolog 1, B7-H1
详细信息
特异性
FURTHER INFORMATION ON SPECIFICITY (Chinese Version) available under the product protocols section. This file includes key technical notes of experience when using this product.
背景信息
Anti-PD-L1 antibody [EPR19759] (ab213524) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), ICC/IF, IHC-P, IP, WB in human samples. Anti-PD-L1 antibody [EPR19759] (ab213524) has been cited over 96 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-PD-L1 antibody [EPR19759] (ab213524) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-PD-L1 antibody [EPR19759] (ab213524) has been confirmed by testing in knockout samples. Anti-PD-L1 antibody [EPR19759] (ab213524) specifically detects PD-L1 (UniProt ID: Q9NZQ7; Molecular weight: 31kDa) and is sold in 100 uL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR19759 - ab221612. Antibody clone EPR19759 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor® 488, Alexa Fluor® 647, HRP, Alexa Fluor® 594, Alexa Fluor® 568 ( ab214958, ab215251, ab215349, ab216742, ab22314 ). Programmed death-ligand 1 (PD-L1) is a critical protein in immuno-oncology, playing a significant role in tumor immune evasion. It is expressed on the surface of tumor cells and binds to the PD-1 receptor on T cells, inhibiting their activity and allowing tumors to escape immune detection. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (169)
MCUB Inhibits PRKN-Dependent Mitophagic Degradation of PD-L1 to Promote Immune Evasion in Bladder Cancer.
MCUB抑制PRKN依赖的PD-L1线粒体自噬降解,从而促进膀胱癌的免疫逃逸。
Dual-dimensional profiling of host genomic variations and HPV integration in PD-L1-stratified cervical cancer via Oxford Nanopore Technology.
利用牛津纳米孔技术对PD-L1分层宫颈癌中的宿主基因组变异和HPV整合进行双维分析。
MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway.
MMP11 通过 PD-L1/c-Myc 信号通路促进食管癌细胞的免疫逃逸。
Gut Associated Metabolites Enhance PD-L1 Blockade Efficacy in Prostate Cancer.
肠道相关代谢物增强 PD-L1 阻断剂在前列腺癌中的疗效。
Pan-cancer analysis of TRPV1: a novel immune infiltration-related biomarker for tumor prognosis and immunotherapy response prediction.
TRPV1 的泛癌分析:一种用于肿瘤预后和免疫治疗反应预测的新型免疫浸润相关生物标志物。
Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma
双重靶向 PD-L1 和 4-1BB 以克服滤泡性淋巴瘤中树突状细胞介导的来那度胺耐药性
Alterations in PD-L1 succinylation shape anti-tumor immune responses in melanoma.
PD-L1琥珀酰化改变影响黑色素瘤的抗肿瘤免疫反应
Targeting chaperone-mediated autophagy inhibits properties of glioblastoma stem cells and restores anti-tumor immunity.
靶向分子伴侣介导的自噬可抑制胶质母细胞瘤干细胞的特性并恢复抗肿瘤免疫力。
Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway
抑制肿瘤内在的NAT10可通过MYC/CDK2/DNMT1通路触发I型干扰素反应,从而增强抗肿瘤免疫力。
Early growth response 1 as a key regulator of PD-L1 expression and immune evasion in extranodal NK/T-cell lymphoma
早期生长反应1是结外NK/T细胞淋巴瘤中PD-L1表达和免疫逃逸的关键调节因子
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