Anti-cleaved N-terminal GSDMD antibody [EPR20829-408] (Ab215203)

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• WB1/1000 We recommend using a higher sensitive ECL substrate to increase the band intensity.

Product Specifications Anti-cleaved N-terminal GSDMD antibody [EPR20829-408] (ab215203) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in WB in human samples. Anti-cleaved N-terminal GSDMD antibody [EPR20829-408] (ab215203) specifically detects cleaved N-terminal GSDMD (UniProt ID: P57764; Molecular weight: 53kDa) and is sold in 100 µL and 1 mL selling sizes. Quality and Validation Abcam's high quality manufacturing and validation processes ensure Anti-cleaved N-terminal GSDMD antibody [EPR20829-408] (ab215203) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-cleaved N-terminal GSDMD antibody [EPR20829-408] (ab215203) has been cited over 114 times in peer reviewed journals and is trusted by the scientific community. Related Products Conjugation-ready, carrier free format available for antibody clone EPR20829-408 - ab255983. Target Information Cleaved N-terminal GSDMD (Gasdermin D) is an important protein fragment involved in the execution of pyroptosis, an inflammatory form of cell death. The N-terminal fragment, generated by cleavage, creates pores in the cell membrane, leading to cell death and the release of inflammatory cytokines. Abnormal regulation of cleaved N-terminal GSDMD is associated with various diseases, including inflammatory disorders like rheumatoid arthritis and neurodegenerative diseases such as Alzheimer's disease, contributing to sustained inflammation and tissue damage. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.