Anti-FOXP3 antibody [EPR22102-37] (Ab215206)
IPEX, JM2, FOXP3, Forkhead box protein P3, Scurfin
详细信息
特异性
We do not guarantee WB for rat. According to our preliminary WB data, this antibody failed to detect endogenous expression of FOXP3 in the tissues tested in WB, such as thymus. It might work in CD4+CD25+ Treg cells with abundant FOXP3, but we don't have experimental data to support that.
背景信息
Anti-FOXP3 antibody [EPR22102-37] (ab215206) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IP, WB in human, mouse, rat samples. Anti-FOXP3 antibody [EPR22102-37] (ab215206) has been cited over 67 times in peer reviewed journals and is trusted by the scientific community. Abcams high quality manufacturing and validation processes ensure Anti-FOXP3 antibody [EPR22102-37] (ab215206) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. Anti-FOXP3 antibody [EPR22102-37] (ab215206) has 5 independent reviews from customers. Anti-FOXP3 antibody [EPR22102-37] (ab215206) specifically detects FOXP3 (UniProt ID: Q9BZS1; Molecular weight: 47kDa) and is sold in a convenient trial size to enable initial testing (20 uL) and larger sizes for subsequent scaling up experiments (100 uL and 1 mL). Conjugation-ready, carrier free format available for antibody clone EPR22102-37 - ab244242. FOXP3 is a key transcription factor that regulates the development and function of regulatory T cells (Tregs), which help maintain immune tolerance. In oncology, high FOXP3 expression is often linked to poor prognosis as it can enable tumors to evade the immune system. This makes FOXP3 a potential biomarker for predicting the effectiveness of immunotherapy treatments. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.
文献引用 (162)
Endothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome
内皮细胞-Treg细胞通过细胞外囊泡转移进行通讯,加剧急性呼吸窘迫综合征
Stress-Programmed Immune Niches Fuel TNFR2+ Treg Activation and Drive Neoadjuvant Chemotherapy Resistance in Breast Cancer.
应激编程的免疫微环境促进 TNFR2+ Treg 激活,并驱动乳腺癌新辅助化疗耐药性。
Globo H ceramide confers chemoresistance and poor prognosis to advanced gallbladder cancer via A2AR/cAMP/PKA pathway.
Globo H 神经酰胺通过 A2AR/cAMP/PKA 通路赋予晚期胆囊癌化疗耐药性和不良预后。
Inflammation-triggered self-immolative conjugates enable oral peptide delivery by overcoming gastrointestinal barriers.
炎症触发的自毁性缀合物能够克服胃肠道屏障,实现口服肽递送。
Enhancing gastric cancer immunotherapy: Insights from multi-omics analysis and innovations in photodynamic-chemotherapy nanoplatforms.
增强胃癌免疫疗法:来自多组学分析和光动力化学疗法纳米平台创新的见解。
Brain-targeting nanoplatform repurposing silymarin for enhanced GBM immunotherapy via synergistic mitochondrial suppression.
利用水飞蓟素靶向大脑,通过协同抑制线粒体来增强胶质母细胞瘤免疫疗法的纳米平台。
CCL5 deficiency aggravates acute DSS-induced colitis by restricting IL-33-induced formation of Tregs in intestinal tract.
CCL5 缺乏会通过限制肠道中 IL-33 诱导的 Treg 形成来加重急性 DSS 诱导的结肠炎。
Tregs Promote Astrocyte-Neuron Lactate Shuttle via Inhibiting STING Pathway to Improve Neurological Recovery After Ischemic Stroke.
Tregs通过抑制STING通路促进星形胶质细胞-神经元乳酸穿梭,从而改善缺血性中风后的神经功能恢复。
The inhibition of miR-125b-5P prevented Treg differentiation through activating STAT3/HIF-1α pathway in PBMCs of ankylosing spondylitis.
抑制 miR-125b-5P 可阻止强直性脊柱炎患者 PBMC 中 STAT3/HIF-1α 通路分化。
Extracellular vesicles derived from hADSCs rescue acute pancreatitis by carrying p-STK3 to regulate Treg differentiation.
源自 hADSCs 的细胞外囊泡通过携带 p-STK3 调节 Treg 分化来挽救急性胰腺炎。
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