Anti-GSDMD antibody [EPR20859] (Ab219800)

特异性

This antibody can detect full length, as well as a N-terminal fragment after stimulation in WB. Expression level of GSDMD in whole normal brain lysate is low or undetectable (PMID: 32671214, PMID: 34975487), we recommend loading higher amount of lysate or using lower antibody dilution. Please see documentation for further information on positive controls (Chinese version)

Anti-GSDMD antibody [EPR20859] (ab219800) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Flow Cyt (Intra), IHC-P, IP and WB. Anti-GSDMD antibody [EPR20859] (ab219800) was first used in a scientific publication in 2019 and has been cited over 152 times in peer reviewed journals. It's performance in Western Blot in mouse and rat samples is trusted by the scientific community. Abcam's high quality manufacturing and validation processes ensure Anti-GSDMD antibody [EPR20859] (ab219800) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility. The specificity of Anti-GSDMD antibody [EPR20859] (ab219800) has been confirmed by Western Blot testing in GSDMD knockout Mouse liver and mouse lung whole cell lysates cells. Anti-GSDMD antibody [EPR20859] (ab219800) specifically detects GSDMD (UniProt ID: Q9D8T2; Molecular weight: 54kDa) and is sold in 100 µL and 1 mL selling sizes. Conjugation-ready, carrier free format available for antibody clone EPR20859 - ab239377. Antibody clone EPR20859 is also available pre-conjugated to a variety of labels for your convenience - Alexa Fluor ® 488, PE, Alexa Fluor ® 647, FITC ( ab246711, ab246713, ab319081, ab322296 ). Gasdermin D (GSDMD) is crucial in inflammasomes for executing pyroptosis and releasing pro-inflammatory cytokines. GSDMD is implicated in autoimmune diseases like IBD. Patented technology Our RabMAb ® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb ® patents. What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free batch production For more information, read more on recombinant antibodies.