Anti-Fibronectin antibody (Ab2413)
FN, FN1, Fibronectin, Cold-insoluble globulin, CIG
详细信息
背景信息
Anti-Fibronectin antibody (ab2413) is a rabbit polyclonal antibody and is validated for use in ICC/IF, IHC-P, WB in human samples. Anti-Fibronectin antibody (ab2413) has been cited over 977 times in peer reviewed journals and is trusted by the scientific community. Abcam's high quality validation processes ensure Anti-Fibronectin antibody (ab2413) has high sensitivity and specificity. Anti-Fibronectin antibody (ab2413) has 89 independent reviews from customers. Anti-Fibronectin antibody (ab2413) specifically detects Fibronectin (UniProt ID: P02751; Molecular weight: 269kDa) and is sold in 250 µL selling sizes. Fibronectin (FN1) is a glycoprotein that plays a critical role in the extracellular matrix (ECM) and is significantly upregulated in the tumor microenvironment. Fibronectin (FN1) facilitates tumor angiogenesis, providing essential nutrients to the growing tumor. It also aids in cancer cell invasion and metastasis through interactions with integrins and activation of signaling pathways like FAK/MAPK/ERK and Wnt. Additionally, fibronectin is involved in the epithelial-mesenchymal transition (EMT), which enhances the migratory and invasive capabilities of cancer cells.
文献引用 (1288)
TGF-β-induced fibrotic scar formation limits recovery of spinal cord injury.
TGF-β诱导的纤维化瘢痕形成限制了脊髓损伤的恢复。
ESRRA-ATG5-Mediated mitophagy enhances arginine metabolism to alleviate diabetic kidney disease.
ESRRA-ATG5介导的线粒体自噬增强精氨酸代谢，从而缓解糖尿病肾病。
Micro-Organ Chip Deciphers Tumor-Derived G-CSF as Remote Commander of Lung Pre-Metastatic Niche via VEGFA-KDR Cascade.
微型器官芯片揭示肿瘤来源的 G-CSF 通过 VEGFA-KDR 级联反应远程调控肺部转移前微环境。
Amyloid β Instigates Cardiac Neurotrophic Signaling Impairment, Driving Alzheimer's Associated Heart Disease.
β淀粉样蛋白引发心脏神经营养信号传导受损，导致阿尔茨海默病相关心脏病。
Stroma-targeted gene delivery for efficient immunogene therapy against pancreatic cancer.
基质靶向基因递送用于有效治疗胰腺癌的免疫基因疗法。
Targeting renal tubular WWP2 to restore mitochondrial OXPHOS integrity retards the AKI-to-CKD transition.
靶向肾小管 WWP2 以恢复线粒体 OXPHOS 完整性可延缓 AKI 向 CKD 的转变。
Phosphodiesterase 1A overexpression contributes to the progression of renal fibrosis.
磷酸二酯酶 1A 过度表达会促进肾纤维化的进展。
Modulating cell surface chemistry through mild reduction reinforces extracellular-to-intracellular transmission forces and mechano-signaling.
通过温和的还原作用调节细胞表面化学性质，可以增强细胞外到细胞内的传递力和机械信号传导。
3D printing- and cyclic strain-driven engineering of skeletal muscle blocks using enhanced viscoelastic extracellular matrix bioink.
利用增强型粘弹性细胞外基质生物墨水，通过 3D 打印和循环应变驱动工程技术构建骨骼肌块。
Sema3d(hi) Fibroblasts Promote Acute Kidney Injury Fibrotic Progression Through Confining Endothelial Cell Migration.
Sema3d(hi)成纤维细胞通过限制内皮细胞迁移促进急性肾损伤纤维化进展。
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