European Journal of Medicinal Chemistry

Synthesis and evaluation of triazole-containing aryl/acyloxy prodrugs of a BTN3A1 ligand.

Redesigning oxazolidinones as carbonic anhydrase inhibitors against vancomycin-resistant enterococci.

CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids.

以 CHI3L1 为靶点的小分子作为胶质母细胞瘤疗法：基于虚拟筛选的发现、生物物理验证、药代动力学分析和在胶质母细胞瘤球体中的评估

Characterization of a dual degrader of MDM2 and GSPT1.

MDM2和GSPT1双重降解剂的特性分析

Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier.

推进线粒体疗法：靶向线粒体丙酮酸载体的吡唑类抑制剂的合成和药理学评价

Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors.

利用激酶后口袋的结构变异来调节TAM抑制剂的多药理学

Discovery of the first-in-class Aurora B kinase selective degrader.

发现首个Aurora B激酶选择性降解剂

Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors.

设计和合成新型 4-芳基-2-苯甲酰基咪唑类化合物作为秋水仙碱结合位点抑制剂

Investigation into the binding domains of platelet factor 4 unlocks new avenues for the design and synthesis of selective sulfated pseudo-tetrasaccharide aminoglycoside ligands.

对血小板因子 4 结合域的研究为设计和合成选择性硫酸化假四糖氨基糖苷配体开辟了新的途径

Anti-cancer efficacy of novel lonidamine derivatives: Design, synthesis, in vitro, in vivo, and computational studies targeting hexokinase-2.

新型洛尼达明衍生物的抗癌功效：针对己糖激酶-2 的设计、合成、体外、体内和计算研究