Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma
在肝细胞癌中,SIRT7抑制剂通过DDX3X介导的NLRP3炎症小体抑制ERK1/2磷酸化,从而克服索拉非尼耐药性。
期刊:Drug Resist Updat
影响因子:15.800
doi:10.1016/j.drup.2024.101054.
Yuna Kim ,Kwan-Young Jung ,Yun Hak Kim ,Pan Xu ,Baeki E Kang ,Yunju Jo ,Navin Pandit ,Jeongho Kwon ,Karim Gariani ,Joanna Gariani ,Junguee Lee ,Jef Verbeek ,Seungyoon Nam ,Sung-Jin Bae ,Ki-Tae Ha ,Hyon-Seung Yi ,Minho Shong ,Kyun-Hwan Kim ,Doyoun Kim ,Hee Jung Jung ,Chang-Woo Lee ,Kwang Rok Kim ,Kristina Schoonjans ,Johan Auwerx ,Dongryeol Ryu