Deguelin promotes longevity and healthspan through C. elegans fmo-4.

There are multiple approaches to longevity interventions in Caenorhabditis elegans , including genetic factors that are necessary or sufficient for lifespan extension and pharmacological agents that modify physiology to extend lifespan. Many pharmacological interventions act through known genetic pathways to promote longevity. Here, we show that the mitochondrial complex I inhibitor, deguelin, promotes lifespan extension and healthspan in an fmo-4- dependent manner. Our results confirm that deguelin increases lifespan and indicate that deguelin induces and requires multiple FMO enzymes to extend lifespan in C. elegans , suggesting these enzymes may promote longevity in a coordinated fashion.