We used epidemiological data from 21195 patients with cancer and 180407 matched controls, including in-depth analyses in 216 cancer patients, to discover clinical and molecular determinants that predispose cancer patients to breakthrough infections. Patients with B cell malignancies, with differential expression of CD24, CDK14 and PLEKHG1, were most susceptible to breakthrough infections, suggesting that these patients may require more booster immunisations to ameliorate cellular responses and immune protection against COVID-19.
Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination.
COVID-19 mRNA 疫苗接种后突破性感染相关的癌症类型和基因特征
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作者：Zhong Youjia, Li Jiaqi, Lee Ainsley Ryan Yan Bin, Tan Janice Yu Jin, Tay Carina Jing Xuan, Koh Clara Wt, Seow Ethan Yong Tzi, Yap Wee Chee, Wong Shi Yin, Yau Chun En, Low Chen Ee, Tan Kelvin Bryan, Young Barnaby Edward, Su Yan, Devasia Arun George, Dharuman Perumal, Lezhava Alexander, Pandey Rahul, Govindaraju Panneer Selvi, Yee Sidney, Weng Ruifen, Khoo Candy, Tan Shaun Shi Yan, Lee Matilda, Lim Joline, Chan Esther, Ho Carol Lf, Chai Louis Yi Ann, Tan Chee Wah, Lee Soo Chin, Chan Kuan Rong, Sundar Raghav
| 期刊： | NPJ Vaccines | 影响因子： | 6.500 |
| 时间： | 2025 | 起止号： | 2025 May 9; 10(1):90 |
| doi： | 10.1038/s41541-025-01141-w | 研究方向： | 肿瘤 |
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