On-demand nanozyme signal enhancement at the push of a button for the improved detection of SARS-CoV-2 nucleocapsid protein in serum.

只需按一下按钮即可按需增强纳米酶信号,从而提高血清中 SARS-CoV-2 核衣壳蛋白的检测能力

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作者:Bradbury Daniel W, Trinh Jasmine T, Ryan Milo J, Cantu Cassandra M, Lu Jiakun, Nicklen Frances D, Du Yushen, Sun Ren, Wu Benjamin M, Kamei Daniel T
We developed an innovative 3D printed casing that incorporates a lateral-flow immunoassay, dehydrated signal enhancement reagents, and a sealed buffer chamber. With only the push of a button for signal enhancement, our device detected the SARS-CoV-2 N-protein in 40 min at concentrations as low as 0.1 ng mL(-1) in undiluted serum.

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