In order to develop targeted strategies for combating drug resistance it is essential to understand it's basic molecular mechanisms. In an exploratory study we have found several possible indicators of etoposide resistance operating in MCF7VP cells, including up-regulation of ABC transporter genes, modulation of miRNA, and alteration in copy numbers of genes.
Differential gene and microRNA expression between etoposide resistant and etoposide sensitive MCF7 breast cancer cell lines.
依托泊苷耐药和依托泊苷敏感的MCF7乳腺癌细胞系之间的差异基因和microRNA表达
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作者：Moitra Karobi, Im Kate, Limpert Katy, Borsa Alexander, Sawitzke Julie, Robey Rob, Yuhki Naoya, Savan Ram, Huang Da Wei, Lempicki Richard A, Bates Susan, Dean Michael
| 期刊： | PLoS One | 影响因子： | 2.600 |
| 时间： | 2012 | 起止号： | 2012;7(9):e45268 |
| doi： | 10.1371/journal.pone.0045268 | 研究方向： | 细胞生物学 |
| 疾病类型： | 乳腺癌 | ||
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