Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice.

精子RNA在小鼠早期创伤影响的跨代遗传中的作用

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作者:Gapp Katharina, Jawaid Ali, Sarkies Peter, Bohacek Johannes, Pelczar Pawel, Prados Julien, Farinelli Laurent, Miska Eric, Mansuy Isabelle M
Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

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