Fully-Gated Denoising Auto-Encoder for Artifact Reduction in ECG Signals.

Cardiovascular diseases (CVDs) are the primary cause of death worldwide. For accurate diagnosis of CVDs, robust and efficient ECG denoising is particularly critical in ambulatory cases where various artifacts can degrade the quality of the ECG signal. None of the present denoising methods preserve the morphology of ECG signals adequately for all noise types, especially at high noise levels. This study proposes a novel Fully-Gated Denoising Autoencoder (FGDAE) to significantly reduce the effects of different artifacts on ECG signals. The proposed FGDAE utilizes gating mechanisms in all its layers, including skip connections, and employs Self-organized Operational Neural Network (self-ONN) neurons in its encoder. Furthermore, a multi-component loss function is proposed to learn efficient latent representations of ECG signals and provide reliable denoising with maximal morphological preservation. The proposed model is trained and benchmarked on the QT Database (QTDB), degraded by adding randomly mixed artifacts collected from the MIT-BIH Noise Stress Test Database (NSTDB). The FGDAE showed the best performance on all seven error metrics used in our work in different noise intensities and artifact combinations compared with state-of-the-art algorithms. Moreover, FGDAE provides reliable denoising in extreme conditions and for varied noise compositions. The significantly reduced model size, 61% to 73% reduction, compared with the state-of-the-art algorithm, and the inference speed of the FGDAE model provide evident benefits in various practical applications. While our model performs best compared with other models tested in this study, more improvements are needed for optimal morphological preservation, especially in the presence of electrode motion artifacts.