The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.
Rapid 3D Extrusion of Synthetic Tumor Microenvironments.
快速三维挤出合成肿瘤微环境
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作者:Grolman Joshua M, Zhang Douglas, Smith Andrew M, Moore Jeffrey S, Kilian Kristopher A
| 期刊: | Advanced Materials | 影响因子: | 26.800 |
| 时间: | 2015 | 起止号: | 2015 Oct 7; 27(37):5512-7 |
| doi: | 10.1002/adma.201501729 | 研究方向: | 肿瘤 |
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