Postoperative Plasmacytoid Dendritic Cells Secrete IFNα to Promote Recruitment of Myeloid-Derived Suppressor Cells and Drive Hepatocellular Carcinoma Recurrence

术后浆细胞样树突状细胞分泌 IFNα 促进髓系抑制细胞募集并促使肝细胞癌复发

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作者:Li Pang, Oscar W H Yeung, Kevin T P Ng, Hui Liu, Jiye Zhu, Jiang Liu, Xinxiang Yang, Tao Ding, Wenqi Qiu, Yuewen Wang, T L Shirley Chiu, Zhiwei Chen, Chung-Mau Lo, Kwan Man

Significance

IFNα secreted by plasmacytoid dendritic cells drives postoperative immunosuppression and early recurrence of hepatocellular carcinoma, providing new biomarkers and therapeutic targets to improve patient outcomes after surgical resection.

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