Establishment of a human induced pluripotent stem cell line (TAUi008-A) derived from a multiple sclerosis patient

建立源自多发性硬化症患者的人类诱导性多能干细胞系 (TAUi008-A)

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作者:Johanna Lotila, Tanja Hyvärinen, Heli Skottman, Laura Airas, Susanna Narkilahti, Sanna Hagman

Abstract

Multiple sclerosis (MS) is a complex autoimmune disease of the central nervous system where the main pathogenetic events include demyelination and axonal degeneration. Here, we generated a human induced pluripotent stem cell (hiPSC) line from peripheral blood mononuclear cells of an MS patient utilizing Sendai virus reprogramming. The produced hiPSC line expressed pluripotency markers, differentiated into three germ layers, showed a normal karyotype and was free of virus vectors, transgenes and mycoplasma. Established hiPSCs are a valuable source for studies of MS disease modeling and drug discovery.

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