Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.
INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants.
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作者：Andrade Viviane M, Christensen-Quick Aaron, Agnes Joseph, Tur Jared, Reed Charles, Kalia Richa, Marrero Idania, Elwood Dustin, Schultheis Katherine, Purwar Mansi, Reuschel Emma, McMullan Trevor, Pezzoli Patrick, Kraynyak Kim, Sylvester Albert, Mammen Mammen P, Tebas Pablo, Joseph Kim J, Weiner David B, Smith Trevor R F, Ramos Stephanie J, Humeau Laurent M, Boyer Jean D, Broderick Kate E
| 期刊： | NPJ Vaccines | 影响因子： | 6.500 |
| 时间： | 2021 | 起止号： | 2021 Oct 14; 6(1):121 |
| doi： | 10.1038/s41541-021-00384-7 | ||
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