Abstract
The zebrafish (Danio rerio) has become one of the most popular and valuable model organisms for studying rare neuromuscular diseases. Its unique characteristics, including the high number of offspring produced with each mating, transparent eggs, rapid development, and genetic similarity to humans, make this small vertebrate ideal for investigating complex and rare disorders affecting the skeletal muscle, such as Duchenne Muscular Dystrophy (DMD), Limb Girdle Muscular Dystrophies (LGMDs), and Brody Myopathy (BM). Various zebrafish models, both natural mutants and genetically engineered strains, have been developed to study these conditions. These models enable the deciphering of pathogenetic mechanisms, the real-time monitoring of disease progression, high-throughput drug screening, and the testing of novel therapeutic approaches. As research progresses, zebrafish models are likely to play an increasingly crucial role in unravelling the complexities of rare neuromuscular diseases and developing targeted therapies, offering hope for affected patients.