Cancer Cell CD44 Mediates Macrophage/Monocyte-Driven Regulation of Head and Neck Cancer Stem Cells

癌细胞 CD44 介导巨噬细胞/单核细胞驱动的头颈癌干细胞调控

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作者:Karina E Gomez, FangLong Wu, Stephen B Keysar, J Jason Morton, Bettina Miller, Tugs-Saikhan Chimed, Phuong N Le, Cera Nieto, Farshad N Chowdhury, Anit Tyagi, Traci R Lyons, Christian D Young, Hongmei Zhou, Hilary L Somerset, Xiao-Jing Wang, Antonio Jimeno

Significance

These findings establish a mechanistic link between tumor cell CD44, TAM, and CSC properties at the tumor-stroma interface that can serve as a vital area of focus for target and drug discovery.

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