Abstract
Coxsackievirus A2 (CVA2) belongs to the enterovirus group A. In this study, we determined the whole-genome sequences of two strains of CVA2 virus isolated from the faeces of patients with hand, foot and mouth disease in Jinhua, Zhejiang Province, China, in 2024. Their nucleotide and amino acid sequences showed 79.12%-79.50% and 94.47%-94.93% identity with the prototypical Fleetwood strain, respectively, and 97.94% and 98.17% mutual identity, respectively. Recombination analysis showed that the P2 region of the two CVA2 strains recombined with Coxsackievirus A4 (CVA4/JN19838/CHN/2019). This study obtained the whole-genome sequences of two CVA2 strains, enriching the molecular characterization of CVA2 in China.