Development and validation of an analytical method for the determination of 5,5-dimethylhydantoin in various processed food

开发和验证一种测定各种加工食品中5,5-二甲基乙内酰脲的分析方法

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Abstract

5,5-Dimethylhydantoin (DMH) produced by degradation of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) may remain a residue on foods that are not washed or further processed before consumption. However, there is no test method related to DMH in Korea. In this study, DMH was quantified by gas chromatography-mass spectrometer (GC-MS) detector. DMH test method was compared and applied to determine the DMH content in various foods distributed in Korea and Australia. In addition, method validation and measurement uncertainty were performed for the established analytical method. As a result, the determination coefficient value (R(2)) of DMH was more than 0.99. The accuracy was 91.6 to 99.8%, and the precision was 1.1 to 10.8 RSD%. The detection limit was 0.2 mg/kg, and the quantification limit was 0.5 mg/kg. The extended uncertainty of DMH was 0.18. All samples (n = 105) analyzed for applicability review were not detected.

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