Generation of a control human induced pluripotent stem cell line using the defective and persistent Sendai virus vector system

使用缺陷型和持久型仙台病毒载体系统生成对照人类诱导多能干细胞系

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作者:Zhi Zhou, Sho Yoshimatsu, Emi Qian, Mitsuru Ishikawa, Tsukika Sato, Manami Ohtaka, Mahito Nakanishi, Hideyuki Okano

Abstract

The defective and persistent Sendai virus (SeVdp) vector system allows efficient generation of transgene-free induced pluripotent stem cells (iPSCs) from human somatic cells. By leveraging the system, here we report the generation of an iPSC line from somatic fibroblasts of a healthy control donner (female), named KEIOi002-A (also named YG-iPS). The control iPSC line would be a useful resource for stem cell research and regenerative medicine.

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