Abstract
The rapid evolution of digital health technologies has created an urgent need for secure, transparent, and interoperable data management systems. The core problem addressed in this study is the fragmentation of healthcare data and the lack of trust among stakeholders in existing digital health infrastructures. The main goal is to examine how blockchain technology can drive digital health transformation through decentralized data governance and integration with other emerging technologies. To achieve this, the research employs a mixed bibliometric and systematic review methodology, analyzing peer-reviewed publications indexed in the Web of Science and comparing topic hierarchies with outputs from Google Scholar between 2017 and 2024. Using keyword co-occurrence and thematic mapping, six major domains were identified: genomics and precision medicine, telemedicine and mobile health, immersive technologies such as augmented and virtual reality, the Internet of Things and Health 5.0 systems, artificial intelligence and big data integration, and global and regional health management. The findings indicate that blockchain enhances healthcare by improving data security, ensuring traceability, facilitating interoperability across platforms, and enabling real-time data sharing in clinical and research environments. It also supports regulatory compliance and patient-centered data ownership. In conclusion, blockchain serves as a foundational technology for future digital health ecosystems, promoting transparency and decentralization across global health networks. This study contributes to the literature by offering a comprehensive framework for integrating blockchain with digital health innovations, providing valuable guidance for researchers, policymakers, and healthcare technologists.