Abstract
(1) Background: Housing instability, a key social determinant of health, disproportionately affects people who use drugs (PWUD), increasing their risk for adverse outcomes. This study explores the relationship between housing status and drug-related health outcomes among PWUD in an urban setting in the Southeastern United States (US) and determines the cutoff point for the Housing Instability Scale (HIS). (2) Methods: We conducted a cross-sectional survey from July to November 2024 among adult PWUD. Recruitment was through syringe services programs (SSPs), nightlife venues, and community outreach. HIS was used to assess housing status, while cluster analysis and Gaussian Mixture Modeling (GMM) were used to suggest a potential cutoff. Logistic regression models were employed to examine associations between housing instability and health outcomes. (3) Results: Among 164 participants (mean age = 41.2; 79.9% Black/African American), the average HIS score was 3.23. Cluster analysis suggested a singular cutoff, while GMM suggested four levels of housing instability. Multivariate logistic regression revealed that housing instability was significantly associated with infections (AOR = 1.55, p = 0.064), blackouts (AOR = 1.47, p = 0.0457), and seizures (AOR = 1.28, p = 0.0667). Overdose and wounds showed no significant association. SSP use, opioid use, and Xanax use were also identified as potential predictors.