Abstract
BACKGROUND: Early diagnosis and treatment of hypertension in preeclampsia are crucial to prevent complications that threaten both mother and fetus. Dayak onion bulbs contain active compounds that may be beneficial for treating hypertension during pregnancy. AIM: This study aimed to evaluate the effect of 96% ethanol extract of Dayak onion bulbs on reducing blood pressure in mice with experimentally induced preeclampsia. METHODS: Thirty female rats were divided into five groups: two control groups and three treatment groups receiving ethanol extract of Dayak onion bulbs at doses of 90, 100, and 125 mg/kg body weight, respectively. The study was conducted across three laboratories from October 1, 2024 to January 14, 2025. RESULTS: The findings demonstratedthat the 96% ethanol extract of Dayak onion bulbs has potential antihypertensive effects in a preeclampsia model, particularly in reducing systolic blood pressure. However, its effects on diastolic blood pressure require further investigation. CONCLUSION: The96% ethanol extract of Dayak onion bulbs showed a significant antihypertensive effect on systolic blood pressure. Although there was a downward trend in diastolic blood pressure, not all reductions were statistically significant.