LRP-1 promotes cancer cell invasion by supporting ERK and inhibiting JNK signaling pathways
LRP-1通过支持ERK和抑制JNK信号通路促进癌细胞侵袭
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作者：Benoit Langlois, Gwenn Perrot, Christophe Schneider, Patrick Henriet, Hervé Emonard, Laurent Martiny, Stéphane Dedieu
| 期刊： | PLoS One | 影响因子： | 2.900 |
| 时间： | 2010 | 起止号： | 2010 Jul 14;5(7):e11584. |
| doi： | 10.1371/journal.pone.0011584 | 研究方向： | 信号转导、肿瘤 |
| 细胞类型： | 肿瘤细胞 | 信号通路： | MAPK/ERK |
Background
The low-density lipoprotein receptor-related protein-1 (LRP-1) is an endocytic receptor mediating the clearance of various extracellular molecules involved in the dissemination of cancer cells. LRP-1 thus appeared as an attractive receptor for targeting the invasive behavior of malignant cells. However, recent
Conclusions
We identified ERK and JNK as the main molecular relays by which LRP-1 regulates focal adhesion disassembly of malignant cells to support invasion.
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