Development and validation of a quantitative Proximity Extension Assay instrument with 21 proteins associated with cardiovascular risk (CVD-21)

开发并验证含有 21 种与心血管风险相关的蛋白质的定量邻近延伸分析仪器 (CVD-21)

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作者:Agneta Siegbahn, Niclas Eriksson, Erika Assarsson, Martin Lundberg, Andrea Ballagi, Claes Held, Ralph A H Stewart, Harvey D White, Mikael Åberg, Lars Wallentin

Background

Treatment of cardiovascular diseases (CVD) is a substantial burden to healthcare systems worldwide. New tools are needed to improve precision of treatment by optimizing the balance between efficacy, safety, and cost. We developed a high-throughput multi-marker decision support instrument which simultaneously quantifies proteins associated with CVD.

Conclusions

The CVD-21 tool is the very first instrument which with PEA simultaneously quantifies 21 proteins with associations to different CVD. Novel pathophysiologic and prognostic information beyond that of established biomarkers were identified by a number of proteins.

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