Abstract
PURPOSE: Infertility is a growing global health issue that significantly affects quality of life (QoL). Understanding its impact on QoL is essential for developing effective healthcare interventions. This study explored QoL, well-being, and spiritual needs among individuals affected by infertility, with implications for healthcare provision. METHODS: Standardized questionnaire data from an anonymous mixed-methods study that was conducted from October 2022 to January 2023 in Switzerland and addressing QoL (FertiQoL), spiritual needs (SpNQ-20), and psychological well-being (WHO-5) of individuals undergoing fertility treatments. RESULTS: The analysis included 326 participants. FertiQoL scores were lowest in the emotional domain (M = 46.35) and highest in the relational domain (M = 68.51), with a mean overall score of 56.69, indicating moderate QoL impacts. Participants without children reported significantly lower FertiQoL and WHO-5 well-being scores than those with children (p < 0.05). The WHO-5 mean score indicated moderate well-being (M = 13.89). SpNQ-20 results showed the highest needs in inner peace (M = 1.82), followed by generativity (M = 1.09) and existential needs (M = 0.86), with religious needs scoring the lowest (M = 0.43). Participants without children had significantly higher spiritual needs (p < 0.05). CONCLUSION: This study highlights the emotional and spiritual challenges of infertility, revealing differences in experiences between individuals with and without children. It emphasizes the importance of addressing mental health and well-being in infertility care. Further research should focus on the psychological impacts of fertility treatments, including depressive mood states.