Abstract
Arboviral diseases, transmitted primarily by Aedes mosquitoes, represent a growing global health challenge. The spread of dengue, Zika, chikungunya, and yellow fever has been associated with factors such as climate change, urbanization, and increased global mobility. We conducted a systematic review of the literature published between January 2000 and December 2024, screening 487 studies, of which 11 met predefined inclusion criteria and were included in the final synthesis (PROSPERO registration: CRD42021231605). The review integrates evidence from epidemiological reports, molecular surveillance studies, and evaluations of control strategies across endemic and emerging regions. Findings indicate a marked geographic expansion of major arboviruses beyond traditional endemic zones, with multiple studies reporting substantial increases in incidence in temperate regions over the past two decades. Molecular analyses consistently demonstrate high genetic diversity and ongoing viral evolution, reflecting adaptation to environmental and host pressures. The review also highlights persistent challenges in disease control, including widespread insecticide resistance, uneven surveillance capacity, and limitations in vaccine deployment. Emerging interventions such as Wolbachia-based vector control, genetically modified mosquitoes, and newer dengue and chikungunya vaccines show promise but require integration within broader surveillance, health-system, and governance frameworks. Overall, the findings underscore the need for coordinated, multisectoral approaches to strengthen early detection, improve control strategies, and mitigate the growing global burden of arboviral diseases.