Abstract
Lesion-deficit mapping is a premier technique for dissociating neural correlates of cognitive functions. However, the contribution of domain-general cognition (g) to the performance of virtually all complex behavioral tasks may encumber such efforts. This possibility has been largely unexplored. Here, we examined the influence of g in lesion-deficit mapping using a combination of structural equation modeling, lesion-behavior mapping (LBM), and structural (sLNM) and functional (fLNM) lesion network mapping. We modeled latent variables for visuospatial ability, processing speed, language, and anterograde memory among 473 patients with focal brain damage (age range 20-93, 257 men, 216 women), both with and without gassociated variance embedded within each factor. Lesion-deficit maps for domain-specific cognitive abilities were statistically significantly less spatially inter-correlated after partitioning out g (p = 0.010 for LBM; p = 0.003 for sLNM; p = 0.003 for fLNM). Lesion-deficit maps also implicated the existence of distinct neuroanatomy for specific cognitive domains that was, in many cases, only apparent and clearly distinct from lesion-deficit maps of g after partitioning out the influence of g. Overall, our findings suggest that, if left unaccounted for, domain-general cognitive variance could tangibly affect conclusions about the extent to which different cognitive functions rely on distinct neuroanatomy.