Connective tissue growth factor in regulation of RhoA mediated cytoskeletal tension associated osteogenesis of mouse adipose-derived stromal cells

结缔组织生长因子在调节 RhoA 介导的细胞骨架张力相关小鼠脂肪基质细胞成骨中的作用

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作者:Yue Xu, Diane R Wagner, Elena Bekerman, Michael Chiou, Aaron W James, Dennis Carter, Michael T Longaker

Background

Cytoskeletal tension is an intracellular mechanism through which cells convert a mechanical signal into a biochemical response, including production of cytokines and activation of various signaling pathways.

Significance

We conclude that CTGF is important in the regulation of cytoskeletal tension mediated ASC osteogenic differentiation.

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