Benzoazacrown compound: a highly effective chelator for therapeutic bismuth radioisotopes

苯并氮杂冠醚化合物:一种高效的治疗性铋放射性同位素螯合剂

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Abstract

A new benzoazacrown ligand H(4)BATA was synthesized and its complexation ability towards bismuth cations was evaluated. Binding of cation occurs at room temperature in a few minutes and formed complex exhibits the same level of inertness as highly stable complex with the well-known H(4)DOTA in biologically relevant and challenging media under in vivo conditions.

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