Targeting TNF alpha as a novel strategy to enhance CD8(+) T cell-dependent immune response in melanoma?

Tumor Necrosis Factor α (TNF) is a pleiotropic cytokine exhibiting a dual activity in oncoimmunology, either acting as a cytotoxic effector produced by leukocytes or behaving as an immunosuppressive molecule. We have just discovered that TNF signaling impairs the accumulation of tumor-infiltrating CD8(+) T lymphocytes in experimental melanoma.