APC/C-CDH1-Regulated IDH3β Coordinates with the Cell Cycle to Promote Cell Proliferation

APC/C-CDH1调控IDH3β协同细胞周期促进细胞增殖

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作者:Qingnan Wu #, Weimin Zhang #, Liyan Xue, Yan Wang, Ming Fu, Liying Ma, Yongmei Song, Qi-Min Zhan

Significance

These findings show that IDH3β is an APC/C-CDH1 substrate and is expressed in a cell-cycle-dependent manner, highlighting novel molecular cross-talk between the TCA cycle and cell cycle in cancer cells.Graphical Abstract: http://cancerres.aacrjournals.org/content/canres/79/13/3281/F1.large.jpg.

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