Abstract
Gut microbes are considered to be key factors regulating host health and are closely related to tumorigenesis. Although the exact mechanism has not been clearly explained, many studies have shown that specific bacteria can affect cancer-related bioactive molecules, such as p53, Wnt, MAPK, and EGFR. Among them, p53 is the most commonly mutated gene in all tumor types. In this review, we systematically examine the gut microbes and metabolites that affect the tumor process by regulating p53, as well as the role of p53 in shaping the gut microbiota, and discuss their potential in the diagnosis and prognosis of tumors and the application value of clinical anti-tumor therapy. This study provides an important theoretical basis for the in-depth understanding and development of relevant treatment strategies.