Variation in the Chemical Composition of Endemic Specimens of Hedychium coronarium J. Koenig from the Amazon and In Silico Investigation of the ADME/Tox Properties of the Major Compounds

亚马逊地区特有的姜花属植物 J. Koenig 的化学成分变化以及主要化合物的 ADME/Tox 特性的计算机模拟研究

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作者:Jorddy Neves Cruz, Mozaniel Santana de Oliveira, Marcia Cascaes, Suraj N Mali, Srushti Tambe, Cleydson Breno Rodrigues Dos Santos, Maria das Graças Bichara Zoghbi, Eloisa Helena de Aguiar Andrade

Abstract

Four species of the genus Hedychium can be found in Brazil. Hedychium coronarium is a species endemic to India and Brazil. In this paper, we collected six specimens of H. coronarium for evaluation of their volatile chemical profiles. For this, the essential oils of these specimens were extracted using hydrodistillation from plant samples collected in the state of Pará, Brazil, belonging to the Amazon region in the north of the country. Substance compounds were identified with GC/MS. The most abundant constituent identified in the rhizome and root oils was 1,8-cineole (rhizome: 35.0-66.1%; root: 19.6-20.8%). Leaf blade oil was rich in β-pinene (31.6%) and (E)-caryophyllene (31.6%). The results from this paper allow for greater knowledge about the volatile chemical profile of H. coronarium specimens, in addition to disseminating knowledge about the volatile compounds present in plant species in the Amazon region.

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