Abstract
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? Lymphocytic choriomeningitis virus (LCMV) is transmitted primarily through rodent excreta, with humans being universally susceptible to infection. Transmission via organ transplantation occurs rarely. The predominantly nonspecific clinical presentation in humans has contributed to LCMV remaining an underrecognized zoonotic pathogen. WHAT IS ADDED BY THIS REPORT? This study provides the first serological confirmation of past LCMV infection among the general population in Gansu Province, with seroprevalence rates of 18.31% by enzyme-linked immunosorbent assay (ELISA) and 1.97% by immunofluorescence analysis (IFA). Priority populations for targeted LCMV prevention and control interventions include rural residents, individuals with lower educational attainment, and agricultural workers. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? LCMV clinical manifestations overlap with those of pathogens targeted by national sentinel surveillance systems; LCMV should be incorporated into future screening protocols for unidentified infectious agents.