Abstract
The human vaginal microbiome (VMB) is a complex and unique ecosystem composed of various microorganisms, including bacteria, fungi, archaea, viruses, and candidate phyla radiation. A healthy VMB is often characterized by the presence of Lactobacillus species, which play a crucial role in protecting and maintaining homeostasis within the vaginal environment. When this balance is disrupted, the protection of the vaginal epithelium weakens, leading to a reduction in Lactobacillus species and an increased risk of various gynecological and reproductive health issues. However, this generalized description can lead to misconceptions and an incomplete understanding of vaginal health, as Lactobacillus is not always dominant across all ages and racialized groups. Therefore, this review provides a comprehensive analysis of the environmental, biological, and racial influences on the VMB at each stage of a woman's life, highlighting their implications for gynecological health and offering a holistic understanding of the VMB for all women.