Abstract
BACKGROUND: Effective countermeasures against emerging infectious diseases require an understanding of transmission rate and basic reproduction number (R(0)). R(0) for severe acute respiratory syndrome is generally considered to be >1, whereas that for Middle East respiratory syndrome (MERS) is considered to be <1. However, this does not explain the large-scale outbreaks of MERS that occurred in Kingdom of Saudi Arabia (KSA) and South Korean hospitals. AIM: To estimate R(0) in nosocomial outbreaks of MERS. METHODS: R(0) was estimated using the incidence decay with an exponential adjustment model. The KSA and Korean outbreaks were compared using a line listing of MERS cases compiled using publicly available sources. Serial intervals to estimate R(0) were assumed to be six to eight days. Study parameters [R(0) and countermeasures (d)] were estimated by fitting a model to the cumulative incidence epidemic curves using Matlab. FINDINGS: The estimated R(0) in Korea was 3.9 in the best-fit model, with a serial interval of six days. The first outbreak cluster in a hospital in Pyeongtaek had an R(0) of 4.04, and the largest outbreak cluster in a hospital in Samsung had an R(0) of 5.0. Assuming a six-day serial interval, the KSA outbreaks in Jeddah and Riyadh had R(0) values of 3.9 and 1.9, respectively. CONCLUSION: R(0) for the nosocomial MERS outbreaks in KSA and South Korea was estimated to be in the range of 2-5, which is significantly higher than the previous estimate of <1. Therefore, more comprehensive countermeasures are needed to address these infections.