Abstract
BACKGROUND: Intrathecal contrast-enhanced magnetic resonance imaging (MRI), utilizing the contrast agent gadobutrol as cerebrospinal fluid (CSF) tracer is emerging as a useful method to study glymphatic function in the human brain. A consistent finding with this technique is large inter-individual variability regarding tracer propagation. In this study, we outline an approach which predicts the distribution of tracer in the parenchyma based only on geometric information from brain tissue as captured by MRI, addressing one possible explanation for this variability. METHODS: Registrations are computed from pre-injection MRI, and used to map images at [Formula: see text] hours after tracer injection to perform predictions of tracer enrichment in the parenchyma in other patients. We apply the method to a dataset of human brain MRI of [Formula: see text] patients examined for different tentative diagnoses including idiopathic normal pressure hydrocephalus, spontaneous intracranial hypotension and idiopathic intracranial hypertension, as well as a group of reference patients. RESULTS: Tracer enrichment mapped between patients by image registration correlate strongly with actual observed enrichment. For patients in the reference group, the relative root mean squared error on our predictions is on average [Formula: see text] in the gray matter, and [Formula: see text] or less in other brain regions. Predictions are generally less reliable in the gray matter, and for patients with identified CSF leaks. CONCLUSION: We show that predictions made from purely geometrical considerations correlate strongly with actual MRI tracer enrichment for patients with similar diagnoses, thus quantifying the role of geometry in tracer enrichment.