Obesity reduces bone density associated with activation of PPARγ and suppression of Wnt/β-catenin in rapidly growing male rats
肥胖降低快速生长雄性大鼠的骨密度，与 PPARγ 的激活和 Wnt/β-catenin 的抑制有关
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作者：Jin-Ran Chen, Oxana P Lazarenko, Xianli Wu, Yudong Tong, Michael L Blackburn, Kartik Shankar, Thomas M Badger, Martin J J Ronis
| 期刊： | PLoS One | 影响因子： | 2.900 |
| 时间： | 2010 | 起止号： | 2010 Oct 28;5(10):e13704. |
| doi： | 10.1371/journal.pone.0013704 | 种属： | Mouse |
| 研究方向： | 信号转导 | 信号通路： | Wnt/β-Catenin |
Background
It is well established that excessive consumption of a high fat diet (HFD)
Significance
These observations strongly suggest that increased NEFA in serum from rats made obese by HFD-feeding impaired bone formation due to stimulation of bone marrow adipogenesis. These effects of obesity on bone in early life may result in impaired attainment of peak bone mass and therefore increase the prevalence of osteoporosis later on in life.
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