Abstract
Antimicrobial autophagy is a host cellular process that captures and delivers intracellular parasites to lysosomes following their targeting as cargo via ubiquitination. Huett et al. (2012) show that the LRR- and RING-domain-containing E3 ubiquitin ligase LRSAM1 recognizes various bacteria and generates a ubiquitin signal that initiates the autophagic cascade.