Abstract
Histoplasma capsulatum is a dimorphic fungus commonly associated with localized pulmonary disease but can often spread to various organs causing disseminated histoplasmosis. Once the disseminated disease reaches the central nervous system (CNS), mortality rates increase significantly and can reach up to 40 %. The prognosis is frequently determined by adequate and timely diagnosis. Treatment often includes amphotericin B for a total of 4-6 weeks followed by itraconazole for at least 1 year. Herein, we present the case of a 65-year-old male who initially presented with worsening headaches and was later found to have disseminated histoplasmosis.