The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells
Notch配体DLL1在人类乳腺癌细胞中发挥致癌作用
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作者:Joana Sales-Dias ,Gabriela Silva ,Márcia Lamy ,Andreia Ferreira ,Ana Barbas
| 期刊: | PLoS One | 影响因子: | 2.900 |
| 时间: | 2019 | 起止号: | 2019 May 20;14(5):e0217002. |
| doi: | 10.1371/journal.pone.0217002 | 种属: | Human |
| 方法学: | WB | 研究方向: | 信号转导、肿瘤 |
| 疾病类型: | 乳腺癌 | 细胞类型: | 肿瘤细胞 |
| 信号通路: | Notch | |
Abstract
These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, suggesting that DLL1 contributes to BC through various mechanisms.
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